CD106 (VCAM-1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD106 (VCAM-1), Rat |
| Clone | REA1078 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | Vio Bright B515 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD106 (VCAM-1) Antibody, anti-rat, Vio® Bright B515, REAfinity™. Clone REA1078 recognizes the CD106 antigen, a 110 kDa transmembrane protein also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow stromal cells, myeloid cells, and dendritic cells, but not on peripheral leukocytes. Expression on endothelial cells is upregulated upon inflammatory cytokine stimulation. CD106 (VCAM-1) is an endothelial ligand for the very late antigen-4 (VLA-4 or α4β1) of the β1 subfamily of integrins, and for integrin α4β7. It mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. CD106 also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis. | Additional information: Clone REA1078 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | VCAM1, VCAM1B |
| Gene, Accession # | Gene ID: 25361 |
| Catalog # | 130-119-192 |
| Price | $200 |
| Order / More Info | CD106 (VCAM-1), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Hession, C. et al. (1992) Cloning of murine and rat vascular cell adhesion molecule-1. Biochem. Biophys. Res. Commun. 183 (1): 163-169. | Barreiro, O. et al. (2002) Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes. J. Cell Biol. 157 (7): 1233-1245. | Gao, Z. et al. (2012) Vascular endothelial growth factor participates in modulating the C6 glioma-induced migration of rat bone marrow-derived mesenchymal stem cells and upregulates their vascular cell adhesion molecule-1 expression. Exp Ther Med. 4 (6): 993-998. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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