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Antigenic Specificity | QA-2, Mouse |
Clone | REA523 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | QA-2 Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA523 recognizes the mouse Qa-2 antigen, a 40 kDa single-pass type I membrane protein, which is also known as H-2 class I histocompatibility antigen Q7 alpha chain (H2-Q7). Qa-2 is a murine non-classical MHC class I molecule involved in the modulation of immune responses by interacting with T CD8+ and NK cell inhibitory receptors. The murine Qa-2 genes map to the H-2Q region, between the classical class I H-2D locus and the H-2TL cluster of class lb sequences. This locus encodes a variable number of class Ib genes in different strains. Strains expressing high (Qa-2high), medium (Qa-2med), low (Qa-2low), and no Qa-2 (Qa-2nul) were identified. Qa-2 is found as membrane-bound and soluble isoforms generated by alternative splicing. It is expressed mostly by lymphoid-derived cells and plays an important role in controlling growth and murine fetal development and, like HLA-G, the molecule is related to the protection of the fetus by inhibiting maternal NK cell-mediated lysis. | Additional information: Clone REA523 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | H2-Qa2, H2-Q7, H2-Q7 |
Gene, Accession # | Gene ID: 15018, 110558, 15019 |
Catalog # | 130-107-909 |
Price | $167 |
Order / More Info | QA-2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Melo-Lima, B. L. et al. (2014) Differential transcript profiles of MHC class Ib(Qa-1, Qa-2, and Qa-10) and Aire genes during the ontogeny of thymus and other tissues. J Immunol: . | Devlin, J. J. et al. (1985) Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. EMBO J. 4 (12): 3203-3207. | Lu, N. et al. (2011) Dynamic expression of Qa-2 during acute graft rejection. Mol. Med. 17 (3-4): 248-255. |