CD39, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD39, Human |
| Clone | REA739 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD39 Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA739 recognizes the 70-100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5'-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. | Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. | Additional information: Clone REA739 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80 |
| Gene, Accession # | Gene ID: 953 |
| Catalog # | 130-128-632 |
| Price | $340 |
| Order / More Info | CD39, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol 153 (8): 3574-3583. | Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271 (51): 33116-33122. | Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by FoxP3+ reg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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