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Antigenic Specificity | CD226 (DNAM-1), Human |
Clone | REA1040 |
Host Species | Recombinant Human |
Reactive Species | human, nonhuman primate |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD226 (DNAM-1) Antibody, anti-human, PE, REAfinity™. Clone REA1040 recognizes the human CD226 (DNAM-1) antigen, a 65 kDa transmembrane glycoprotein expressed on T cells, NK cells, platelets, monocytes, and a subset of B cells. It is also expressed by a subset of CD3+ thymocytes. The surface association of CD226 (DNAM-1) with LFA-1 on NK cells and T cells permits the transduction of cytolytic signals upon binding of CD226 (DNAM-1) to its ligands CD155 (PVR) and CD112 (Nectin-2). | Additional information: Clone REA1040 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | DNAM-1, PTA-1, TLiSA1 |
Gene, Accession # | Gene ID: 10666 |
Catalog # | 130-117-638 |
Price | $121 |
Order / More Info | CD226 (DNAM-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4: 573-581. | Bottino, C. et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198: 557-567. | Kojima, H. et al. (2003) CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J. Biol. Chem. 278: 36748-36753. | Castriconi, R. et al. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accesory molecule-1-poliovirus receptor interaction. Cancer Res. 64: 9180-9184. | Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259. | Pende, D. et al. (2005) Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 105: 2066-2073. |