PIR-B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityPIR-B, Mouse
CloneREA899
Host SpeciesRecombinant Human
Reactive Speciesmouse
IsotypeIgG1
Formatbiotin conjugate
Size30 µg in 200 µL
Concentration1:50
ApplicationsFlow cytometry
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DescriptionPIR-B Antibody, anti-mouse, Biotin, REAfinity™. Clone REA899 recognizes the B isoform of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIRs functions as receptors for class I MHC antigens. PIR-B down-regulates antigen-induced B cell-activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). | Additional information: Clone REA899 displays negligible binding to Fc receptors.
Immunogenn/a
Other Names6M21, Ly89, GP91, LIR-3, LILRB3
Gene, Accession #Gene ID: 18733
Catalog #130-114-873
Price$64
Order / More InfoPIR-B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesKubagawa, H. et al. (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5261-5266. | Blery, M. et al. (1998) The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2446-2451. | Kubagawa, H. et al. (1999) Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. J. Exp. Med. 189 (2): 309-318.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

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