AKT pS473, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | AKT pS473, Human/Mouse |
| Clone | REA359 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 µg in 100 µL |
| Concentration | n/a |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | AKT pS473 Antibody, anti-human/mouse, pure, REAfinity™. Clone REA359 recognizes the human and mouse Akt antigen phosphorylated at serine 473 (pS473). Akt is a family of serine/threonine kinases which is also known as protein kinase B (PKB) or related to the A and C kinases (RAC-PK). Akt intricately regulates many cellular functions such as cell growth and proliferation, cell survival, apoptosis, energy metabolism, and resistance to anticancer therapeutics. It consists of three isoforms, Akt1, Akt2, and Akt3 (or PKBα, β, and γ). Although these three isoforms are encoded by separate genes, they share a common NH2-terminal pleckstrin homology (PH) domain, a catalytic domain in the middle, and a COOH terminus. The identity of the overall amino acid sequence of the three isoforms is very high (about 80%); however, the COOH terminus and the PH-linker region are more diverse. All three isoforms contain similar phosphorylation/activation sites: threonine 308 (Akt1), 309 (Akt2), and 305 (Akt3) and serine 473 (Akt1), 474 (Akt2), and 472 (Akt3). Phosphorylated or activated Akt regulates many of its cellular functions through the phosphorylation of a series of downstream players. | Additional information: Clone REA359 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | Akt1, CWS6, PKB, PKB-ALPHA, RAC, RAC-ALPHA, PKBγ, PKBβ, STK-2 |
| Gene, Accession # | Gene ID: 11651, 207 |
| Catalog # | 130-122-340 |
| Price | $207 |
| Order / More Info | AKT pS473, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Calamito, M. et al. (2010) Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood 115: 4043-4050. | Arranz, A. et al. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. U.S.A. 109 (24): 9517-9522. | Santi, S. A. et al. (2010) The Akt isoforms are present at distinct sub cellular locations. Am. J. Physiol., Cell Physiol. 298 (3): 580-591. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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