FAK pS910, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | FAK pS910, Human |
| Clone | REA407 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FAK pS910 Antibody, anti-human, PE, REAfinity™. Clone REA407 recognizes the human focal adhesion kinase (FAK) antigen phosphorylated at serine 910 (pS910). FAK is a 125 kDa non-receptor and non-membrane cytoplasmic tyrosine kinase that plays critical roles in integrin-mediated signal transductions and also participates in signaling by other cell surface receptors. In integrin-mediated cell adhesion, FAK is activated via disruption of an auto-inhibitory intra-molecular interaction between its amino terminal FERM domain and the central kinase domain. The activated FAK forms a complex with Src family kinases, which initiates multiple downstream signaling pathways through phosphorylation of other proteins to regulate different cellular functions. Those signaling pathways are identified to mediate FAK regulation of migration of various normal and cancer cells. Serine 910 (pS910) is a prominent site differentially phosphorylated in response to neurotransmitters, bioactive lipids, tumor promoters, and growth factors in intestinal epithelial cells. | Additional information: Clone REA407 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1 |
| Gene, Accession # | Gene ID: 5747 |
| Catalog # | 130-126-513 |
| Price | $365 |
| Order / More Info | FAK pS910, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Jiang, X. et al. (2007) Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell. Signal. 19 (5): 1000-1010. | Zhao, X. et al. (2011) Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv. Drug Deliv. Rev. 63 (8): 610-615. | Whitney, G. S. et al. (1993) Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. DNA Cell Biol. 12 (9): 823-830. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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