NLRP3 (NALP3), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | NLRP3 (NALP3), Human/Mouse |
| Clone | REA668 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | NLRP3 (NALP3) Antibody, anti-human/mouse, PE, REAfinity™. Clone REA668 recognizes the human and mouse NLRP3 antigen, also known as NACHT, LRR, and PYD domains-containing protein 3 (NALP3). NLRP3, a member of the NLR family of cytosolic receptors, is a pyrin-like protein which contains a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. NLRP3 plays a crucial role in innate immunity and inflammation and is a pathogen recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs). NLRP3 is an important regulator of caspase-1, the enzyme that processes the immature form of IL-1β into the active protein. NLRP3 is mainly expressed in macrophages, but also expressed in dendritic cells, B cells, T cells, and osteoblasts. | Additional information: Clone REA668 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | NACHT, LRR, PYD domains-containing protein 3, NALP3, cryopyrin |
| Gene, Accession # | Gene ID: 114548, 216799 |
| Catalog # | 130-111-209 |
| Price | $310 |
| Order / More Info | NLRP3 (NALP3), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | McCall, S. H. et al. (2008) Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J. Bone Miner. Res. 23 (1): 30-40. | Bae, J. Y. et al. (2011) Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly. J. Biol. Chem. 286 (45): 39528-39536. | Haneklaus, M. et al. (2013) Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. Curr. Opin. Immunol. 25 (1): 40-45. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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