CD205 (DEC205), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD205 (DEC205), Human |
| Clone | REA1080 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD205 (DEC205) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA1080 recognizes the human CD205 (DEC205) antigen, a glycoprotein also known as Ly-75. CD205 is a 210 kDa C-type lectin single-pass membrane protein (type I), which is highly expressed on thymic epithelial cells and dendritic cells. Unlike murine CD205, human CD205 is also found at low levels on other peripheral blood lymphocytes, eg., monocytes, T cells, B cells, and NK cells. CD205 belongs to the macrophage mannose receptor family and acts as an endocytic receptor to uptake antigens, direct the captured antigens from the extracellular space to the antigen-processing compartment for antigen presentation on MHC class II and cross-presentation on MHC class I molecules. Another function of CD205 is the clearance of apoptotic cells, potentially an important pathway for the uptake of self-antigen in intrathymic and peripheral tolerance. | Additional information: Clone REA1080 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | LY75, CLEC13B, DEC-205, GP200-MR6, LY-75 |
| Gene, Accession # | Gene ID: 4065 |
| Catalog # | 130-118-754 |
| Price | $162 |
| Order / More Info | CD205 (DEC205), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Guo, M. et al. (2000) A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum. Immunol. 61 (8): 729-738. | Bonifaz, L. et al. (2004) In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination. J. Exp. Med. 199: 815-824. | Heath, W. et al. (2004) Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunol. Rev. 199: 9-26. | Shrimpton, R. et al. (2009) CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self. Mol. Immunol. 46 (6): 1229-1239. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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