CD197 (CCR7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD197 (CCR7), Human |
| Clone | REA546 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | Vio Bright V600 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD197 (CCR7) Antibody, anti-human, Vio® Bright V600, REAfinity™. Clone REA546 recognizes the human CD197 antigen, which is also known as CCR7. CD197 is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV). For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7+CD45RA+), central memory T cells (CCR7+ CD45RA-), and effector memory T cells (CCR7- CD45RA-). | Additional information: Clone REA546 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1 |
| Gene, Accession # | Gene ID: 1236 |
| Catalog # | 130-131-163 |
| Price | $482 |
| Order / More Info | CD197 (CCR7), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bacher, P. et al. (2014) Identification of immunogenic antigens from Aspergillus fumigatus by direct multi parameter characterization of specific conventional and regulatory CD4+ T cells. J Immunol 193: 3332-3343. | Sallusto, F. et al. (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708-712. | Birkenbach, M. et al. (1993) Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67 (4): 2209-2220. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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