CD352 (NTB-A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Edit | |
|---|---|
| Antigenic Specificity | CD352 (NTB-A), Human |
| Clone | REA339 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD352 (NTB-A) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell-antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352. | Additional information: Clone REA339 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM |
| Gene, Accession # | Gene ID: 114836 |
| Catalog # | 130-105-596 |
| Price | $162 |
| Order / More Info | CD352 (NTB-A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Katz, G. et al. (2014) SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death. J Immunol 192 (9): 4202-4209. | Bottino, C. et al. (2001) NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194 (3): 235-246. | Valdez, P. A. et al. (2004) NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J. Biol. Chem. 279 (18): 18662-18669. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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