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Antigenic Specificity | CD49f, Human/Mouse |
Clone | GoH3 |
Host Species | Rat |
Reactive Species | human, mouse, nonhuman primate, other |
Isotype | IgG2aκ |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunocytochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD49f Antibody, anti-human/mouse, APC. Clone GoH3 reacts with CD49f, a 120 kDa transmembrane glycoprotein also known as α6 integrin. Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Clone GoH3 antibody has been reported to block laminin binding in vitro and to block integrin α6 function in vivo. |
Immunogen | n/a |
Other Names | ITGA6, α6 integrin, ITGA6B, VLA-6, CD49f, VLA-6α |
Gene, Accession # | Gene ID: 3655 |
Catalog # | 130-100-147 |
Price | $142 |
Order / More Info | CD49f, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110 (6): 673-687. | Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188 (1): 55-60. | Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665. | Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154. | Izadyar, F. et al. (2011) Identification and characterization of repopulating spermatogonial stemcells from the adult human testis. Hum. Reprod. 26: 1296-1306. |