Dectin-2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Dectin-2, Mouse |
| Clone | REA1001 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Dectin-2 Antibody, anti-mouse, PE, REAfinity™. Clone REA1001 recognizes the mouse dendritic cell-associated C-type lectin 2 (dectin-2) antigen. Dectin-2 is a type II membrane protein and contains a single carbohydrate recognition domain. Like other C-type lectins, mouse dectin-2 has conserved motifs for the Ca 2)+-dependent recognition of mannose. Dectin-2 is located in the natural killer gene complex of chromosome 6. Genomic analyses show that beside a full length dectin-2 transcript two truncated isoforms are produced by alternative splicing, encoding transmembrane proteins of 168-209 amino acids. The expression of dectin-2 on mouse monocytes and macrophages can be induced by zymosan and thioglycollate. Dectin-2 plays a physiological role in antigen presentation and antigen targeting via dectin-2 can induce a CD8+ T cell response. | Additional information: Clone REA1001 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CLEC4N, Clec6a, Clecsf10, Nkcl |
| Gene, Accession # | Gene ID: 56620 |
| Catalog # | 130-116-910 |
| Price | $71 |
| Order / More Info | Dectin-2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Fernandes, M. J. et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59: 2709-2717. | Ariizumi, K. et al. (2000) Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963. | Taylor, P. R. et al. (2005) Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur. J. Immunol. 35: 2163-2174. | Carter, R. W. et al. (2006) Induction of CD8+ T cell responses through targeting of antigen to Dectin-2. Cell. Immunol. 239: 87-91. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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