Nanog, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Nanog, Human |
| Clone | REA314 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Nanog Antibody, anti-human, Vio® B515, REAfinity™. Clone REA314 recognizes the human Nanog antigen, a homeobox transcription factor also known as ES cell-associated protein 4. Nanog is thought to be a key factor in maintaining pluripotency. It is expressed in the central portion of the morula, the inner cell mass of the blastocyst, in embryonic stem cells (ESC), and embryonic germ cells (EGC). The expression decreases with ESC differentiation. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Inhibition of Nanog expression has led to a reduction in tumorigenicity and such in vitro characteristics of stem cells as anchorage independent growth whereas overexpression may increase tumorigenicity. | Additional information: Clone REA314 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Homeobox protein NANOG, ES cell-associated protein 4, Early embryo specific expression NK-type homeobox protein, Homeobox transcription factor Nanog (hNanog) |
| Gene, Accession # | Gene ID: 79923 |
| Catalog # | 130-129-260 |
| Price | $134 |
| Order / More Info | Nanog, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Costa, Y. et al. (2013) NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature 495 (7441): 370-374. | Wang, Z. et al. (2012) Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell Stem Cell 10 (4): 440-454. | Chambers, I. et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113 (5): 643-655. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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