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Antigenic Specificity | CD221 (IGF-1R), Human |
Clone | REA271 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD221 (IGF-1R) Antibody, anti-human, PE, REAfinity™. Clone REA271 recognizes human CD221 (IGF-1R), a widely expressed cell-surface glycoprotein composed of two α subunits and two β subunits. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain. The α chains are located extracellularly, while the β subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF-1R is activated by binding of its ligands insulin-like growth factor 1 (IGF-1), IGF-2, as well as insulin to the extracellular α subunits. Ligand binding leads to autophosphorylation of tyrosine residues in the cytoplasmic regions of the receptor β subunits and subsequent recruitment and phosphorylation of insulin receptor substrate (IRS) proteins. This finally results in activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells exhibit altered IGF-1R expression. | Additional information: Clone REA271 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | IGF1R, IGFIR, IGFR, JTK13 |
Gene, Accession # | Gene ID: 3480 |
Catalog # | 130-103-972 |
Price | $110 |
Order / More Info | CD221 (IGF-1R), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | n/a |