IL-17A, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | IL-17A, Mouse |
| Clone | REA660 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL-17A Antibody, anti-mouse, FITC, REAfinity™. Clone REA660 recognizes mouse interleukin 17A (IL-17A). Interleukin 17 (IL-17) is a family of cytokines that play a central role in adaptive immunity as well as autoinflammatory disorders. Data from several mouse models suggest that IL-17 plays a key role in the host defense against certain extracellular bacterial infections. | Recently, a new mouse T helper cell subset has been identified, which is dinstinct from T?1 and T?2 cells: IL-17-producing CD4+ T helper (T?17) cells. T?17 cells preferentially produce IL-17A, IL-17F, IL-21, and IL-22. Receptors for IL-17 and IL-22 are expressed on various epithelial tissues, thus T?17 cells are crucial for the cross-talk between immune system and tissues. It is now established that T?17 cells are responsible for driving autoimmune inflammation. After stimulation of mouse T cells, IL-17 is not only secreted by CD4+ T cells, but also by CD8+ T cells and γδ T cells. | Additional information: Clone REA660 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CTLA-8, IL-17 |
| Gene, Accession # | Gene ID: 16171 |
| Catalog # | 130-112-008 |
| Price | $54 |
| Order / More Info | IL-17A, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kennedy, J. et al. (1996) Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells. J. Interferon Cytokine Res. 16 (8): 611-617. | Weaver, C. T. et al. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852. | Ouyang, W. et al. (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467. | Zheng, S. et al. (2017) Human gingiva-derived mesenchymal stem cells ameliorate Streptozoticin-induced T1DM in mice via suppression of T effector cells and up-regulating Treg subsets. Sci Rep 7 (1): 15249. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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