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Antigenic Specificity | TCR Vβ1, Human |
Clone | REA662 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TCR Vβ1 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA662 recognizes the human variable beta 1 subunit of the αβ T cell receptor (TCR Vβ1). The TCR is a heterodimeric glycoprotein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ1 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell-mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell-mediated immunity and underpins MHC restriction. | Additional information: Clone REA662 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | Gene ID: 28621 , 6957 |
Catalog # | 130-128-128 |
Price | $146 |
Order / More Info | TCR Vβ1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2925-2929. | Dunon, D. et al. (1994) T cell migration during development: homing is not related to TCR V beta 1 repertoire selection. EMBO J. 13 (4): 808-815. | van den Beemd, R. et al. (2000) Flow cytometric analysis of the Vbeta repertoire in healthy controls. Cytometry 40 (4): 336-345. | Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40 (1): 27-36. |