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Antigenic Specificity | p120 Catenin pT310, Human |
Clone | REA153 |
Host Species | Recombinant Human |
Reactive Species | human, mouse, other |
Isotype | IgG1 |
Format | PE-Vio 770 conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Intracellular flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | p120 Catenin pT310 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA153 recognizes the threonine residue (T310)-phosphorylated form of p120 Catenin, a prototypic member of subfamily of Armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1-7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 Catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 Catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases. | Additional information: Clone REA153 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | CTNND1, CAS, CTNND, p120cas, p120ctn, p120, Catenin δ-1 |
Gene, Accession # | Gene ID: 1500 |
Catalog # | 130-104-347 |
Price | $162 |
Order / More Info | p120 Catenin pT310, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Liu, X. et al. (2014) Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility and metastasis. Cancer Res. 74 (5): 1609-1620. | Stairs, D. B. et al. (2011) Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell 19 (4): 470-483. | Reynolds, A. B. et al. (2004) Emerging roles for p120-catenin in cell adhesion and cancer. Oncogene 23 (48): 7947-7956. |