CD49e, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD49e, Human |
| Clone | REA686 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD49e Antibody, anti-human, PE, REAfinity™. Clone REA686 recognizes the human CD49e antigen, also known as integrin α5 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cellmatrix interaction. Integrin α5 is composed of a heavy and a light chain linked by a disulfide bond. CD49e associates non-covalently with the integrin β1 (CD29) forming the very late activation antigen-5 (VLA5) complex which is expressed on many cell types including peripheral lymphocytes, monocytes, fibroblasts, and endothelial cells and is a receptor for fibronectin and fibrinogen but functions also as a receptor for laminin and several other extracellular matrix proteins. | Additional information: Clone REA686 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | VLA-5α, α5 integrin, VLA-5, Integrin alpha-5 |
| Gene, Accession # | Gene ID: 3678 |
| Catalog # | 130-110-590 |
| Price | $110 |
| Order / More Info | CD49e, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Riedl, E. et al. (2000) Functional involvement of E-cadherin in TGF-beta 1-induced cell cluster formation of in vitro developing human Langerhans-type dendritic cells. J Immunol 165 (3): 1381-1386. | Takada, Y. et al. (1987) The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 84: 3239-3243. | Takagi, J. et al. (2003) Structure of integrin alpha5beta1 in complex with fibronectin. EMBO J. 22: 4607-4615. | Lomakina, E. B and Waugh, R. E. (2009) Adhesion between human neutrophils and immobilized endothelial ligand vascular cell adhesion molecule 1: divalent ion effects. Biophys. J. 96 (1): 276-284. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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