CD101, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD101, Mouse |
| Clone | REA301 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD101 Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA301 recognizes the mouse CD101 antigen, a type I transmembrane glycoprotein also known as immunoglobulin superfamily member 2 (IgSF2) or V7. CD101 is expressed on monocytes, granulocytes, dendritic cells (DCs), and activated T cells. In humans CD101 inhibits the proliferative response of T cells to allogeneic cells or immobilized anti-CD3 antibody, suggesting that engagement of CD101 can antagonize TCR/CD3-mediated lymphocyte activation. Moreover, human peripheral CD8+ T cells that express CD101 and CD103 display suppressive function after activation with intraepithelial cells or placental trophoblasts. In addition to its role on T cells, triggering CD101 on human cutaneous DCs inhibits T cell proliferation via interleukin 10 (IL-10) production, suggesting that the CD101 molecule may be involved in tolerance induction. Studies in mice showed that cell surface expression of CD101 is highly correlated with functional suppressor activity within CD4+CD25+ T regulatory cells both in vitro and in vivo. | Additional information: Clone REA301 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | EWI-101, Gm1016, Gm734, IGSF2 |
| Gene, Accession # | Gene ID: 630146 |
| Catalog # | 130-104-354 |
| Price | $57 |
| Order / More Info | CD101, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Fernandez, I. et al. (2007) CD101 surface expression discriminates potency among murine FoxP3+ regulatory T cells. J Immunol 179 (5): 2808-2814. | Mohammed, J. P. et al. (2011) Identification of CD101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. J Immunol 187 (1): 337-349. | Penha-Goncalves, C. et al. (2003) Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Diabetes 52 (6): 1551-1556. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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