HLA-DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-DQ, Human |
| Clone | REA303 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-DQ Antibody, anti-human, PE, REAfinity™. Clone REA303 recognizes HLA-DQ, an αβ heterodimer of the MHC class II type. Expressed on the surface of most nucleated cells, MHC class II molecules play an important role in the immune system. They are essential in the defense against infection and are a main consideration in transplantation medicine. In addition to presenting antigenic peptides from predominantly extracellular sources to CD4+ T cells, MHC class II molecules also mediate the thymic selection of T helper cells. MHC class II molecules consist of an α and β chain and are transported to endosomal-lysosomal compartments by the invariant chain. In humans, MHC class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display 70% similarity to each other. Both chains of HLA-DQ are polymorphic. Despite the essential function of MHC class II molecules in immune defense against pathogens, some alleles are frequently linked to immune diseases. Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and diabetes mellitus type 1. | Additional information: Clone REA303 displays negligible binding to Fc receptor | |
| Immunogen | n/a |
| Other Names | HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2 |
| Gene, Accession # | Gene ID: 3117, 3118, 3119, 3120, 3121 |
| Catalog # | 130-104-496 |
| Price | $310 |
| Order / More Info | HLA-DQ, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | van Lith, M. et al. (2010) HLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM. J. Biol. Chem. 285 (52): 40800-40808. | Jones, E. Y. et al. (2006) MHC class II proteins and disease: a structural perspective. Nat. Rev. Immunol. 6 (4): 271-282. | Klitz, W. et al. (2003) New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens 62 (4): 296-307. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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