CD273 (PD-L2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD273 (PD-L2), Mouse |
| Clone | REA986 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD273 (PD-L2) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA986 recognizes CD273, a member of the B7 family of protein ligands. CD273, along with another member of the B7 family (B7-H1) are ligands of T-cell receptor known as programmed death-1 (PD-1). Surface expression of B7-DC is restricted to dendritic cells (DCs) and activated or IFNγ-stimulated DCs and macrophages. CD273/PD-1 interaction is involved in inhibition of T-cell activation, however a co-stimulatory role of CD273, via interaction with receptor other then PD-1 is also reported. | Additional Information: Clone REA986 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PDCD1LG2, B7-DC, Btdc, PD-L2 |
| Gene, Accession # | Gene ID: 58205 |
| Catalog # | 130-116-768 |
| Price | $125 |
| Order / More Info | CD273 (PD-L2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Tseng, S. Y. et al. (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193: 839-846. | Wang, S. et al. (2003) Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 197: 1083. | Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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