APCDD1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | APCDD1, Human |
| Clone | REA887 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | APCDD1 Antibody, anti-human, APC, REAfinity™. Clone REA887 recognizes the human APCDD1 antigen, a single-pass type I membrane glycoprotein also known as adenomatosis polyposis coli down-regulated 1 protein or DRAPC1. APCDD1 functions as a negative regulator of the Wnt signaling pathway, is suggested to be involved in colorectal tumorigenesis, and supports the expression and activation of β-catenin. APCDD1 is highly expressed in heart, pancreas, prostate, ovary, and in the epidermal and dermal compartments of the hair follicle. It is moderately expressed in lung, liver, kidney, spleen, thymus, colon, and peripheral lymphocytes. | Additional information: Clone REA887 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Adenomatosis polyposis coli down-regulated 1 protein, DRAPC1, FP7019 |
| Gene, Accession # | Gene ID: 147495 |
| Catalog # | 130-114-668 |
| Price | $142 |
| Order / More Info | APCDD1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Takahashi, M. et al. (2002) Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis. Cancer Res. 62 (20): 5651-5656. | Shimomura, Y. et al. (2010) APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 464 (7291): 1043-1047. | Viale-Bouroncle, S. et al. (2015) The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells. Biochem. Biophys. Res. Commun. 457 (3): 314-317. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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