CD146 (LSEC), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD146 (LSEC), Mouse |
| Clone | REA1064 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | VioBlue conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD146 (LSEC) Antibody, anti-mouse, VioBlue®, REAfinity™. Clone REA1064 recognizes the mouse CD146 antigen, which is expressed on mouse endothelial cells, including liver sinusoidal endothelial cells (LSECs), smooth muscle cells, and the basal membrane. LSECs are microvascular endothelial cells lining the hepatic sinusoidal wall. Their strategic positioning favors a tight interaction with lymphocytes migrating through the liver. They possess a high capacity for antigen uptake and processing. However, in contrast to professional antigen-presenting cells, e.g. dendritic cells, they express only low levels of costimulatory molecules. | Additional information: Clone REA1064 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MCAM, 1-gicerin, CD149, MUC18, S-endo, s-gicerin, Endo-CAM, Mel-CAM |
| Gene, Accession # | Gene ID: 84004 |
| Catalog # | 130-118-255 |
| Price | $455 |
| Order / More Info | CD146 (LSEC), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Harder, R. et al. (1991) Dissection of murine lymphocyte-endothelial cell interaction mechanisms by SV-40-transformed mouse endothelial cell lines: novel mechanisms mediating basal binding, and alpha 4-integrin-dependent cytokine-induced adhesion. Exp. Cell Res. 197: 259-267. | Diehl, L. et al. (2008) Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance. Hepatology 47: 296-305. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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