Btk, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Btk, Human |
| Clone | REA367 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Btk Antibody, anti-human, PE, REAfinity™. Clone REA367 recognizes the human bruton tyrosine kinase (Btk) antigen, a non-receptor tyrosine kinase belonging to the Tec family of kinases. Btk is critical for B cell-development, -differentiation, and -signaling. Moreover, Btk expression is assumed to be a prerequisite for B cell-proliferation and -survival. Consequently, Btk-deficient B lymphocytes fail to reach the mature state and are presumably doomed to premature death. Btk is reported to be associated with human disease. Thus, individuals harboring loss-of-function mutations in the gene encoding Btk virtually lack circulating B lymphocytes, are unable to generate immunoglobulins of all classes, and therefore cannot mount humoral immune responses. This primary immunodeficiency is named X-linked agammaglobulinemia. | Additional information: Clone REA367 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA |
| Gene, Accession # | Gene ID: 695 |
| Catalog # | 130-116-669 |
| Price | $119 |
| Order / More Info | Btk, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Vetrie, D. et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature 361 (6409): 226-233. | Tsukada, S. et al. (1993) Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72 (2): 279-290. | Mohamed, A. J. et al. (2009) Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol. Rev. 228 (1): 58-73. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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