CD110, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD110, Human |
| Clone | REA250 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD110 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA250 recognizes the CD110 antigen, a type I transmembrane protein and a member of the hematopoietin receptor family, which is also known as myeloproliferative leukemia protein (MPL) or thrombopoietin receptor (TPO-R). CD110 is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets. It serves as a receptor for thrombopoietin and CD110 deficiency leads to severe thrombocytopenia, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. | Additional information: Clone REA250 displays negligible binding to Fc receptors. | | |
| Immunogen | n/a |
| Other Names | MPL, C-MPL, MPLV, THCYT2, TPOR |
| Gene, Accession # | Gene ID: 4352 |
| Catalog # | 130-101-649 |
| Price | $170 |
| Order / More Info | CD110, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Vigon, I. et al. (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. U.S.A. 89: 5640 -5644. | Chou, F. S. et al. (2011) The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis. J. Cell. Biochem. 112 (6): 1491-1498. | Kaushansky, K. et al. (1998) The role of the MPL receptor in myeloproliferative disorders. Leukemia 12: S47-S50. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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