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Antigenic Specificity | Plexin-B2, Mouse |
Clone | REA445 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plexin-B2 Antibody, anti-mouse, APC, REAfinity™. Clone REA445 recognizes the mouse Plexin-B2 antigen, a Single-pass type I membrane protein which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T-dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth and cell migration. It has several semaphorin ligands including Semaphorin-3E, Semaphorin-4A, Semaphorin-4C, and Semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with Plexin-B2 on gamma delta T cells to play a role in the healing process. | Additional information: Clone REA445 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Plxnb2, Debt |
Gene, Accession # | Gene ID: 140570 |
Catalog # | 130-106-336 |
Price | $88 |
Order / More Info | Plexin-B2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Witherden, D. A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37 (2): 314-325. | Deng, S. et al. (2007) Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J. Neurosci. 27 (23): 6333-6347. | Saha, B. et al. (2012) Plexin-B2 regulates the proliferation and migration of neuroblasts in the postnatal and adult subventricular Zone. J. Neurosci. 32 (47): 16892-16905. |