CD184 (CXCR4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD184 (CXCR4), Mouse |
| Clone | REA107 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD184 (CXCR4) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA107 reacts with CD184, a receptor for C-X-C chemokine CXCL12/SDF-1. CD184 is a seven membrane spanning receptor and belongs to the family of G-protein coupled chemokine receptors. Expression of CD184 is found in tissues including spleen, thymus, bone marrow, lymph nodes, and at lower levels in small intestine, kidney, and stomach. Diverse functions of CD184 include promoting survival and proliferation of hematopoietic stem cells, inducing apoptosis in T cells, regulating osteoclastogenesis, B cell development, vascularization of the gastrointestinal tract, germ cell migration/survival, and cerebellar development. CD184 also serves as a co-receptor for entry into target cells by HIV-1 X4 and interacts with extracellular ubiquitin. | Additional information: Clone REA107 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CXCR4, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, b2b220Clo, Fusin, SDF-1 receptor |
| Gene, Accession # | Gene ID: 12767 |
| Catalog # | 130-127-483 |
| Price | $125 |
| Order / More Info | CD184 (CXCR4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Drummond, R. A. et al. (2014) Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis. J Immunol 193 (11): 5381-5385. | Forster, R. et al. (1998) Intracellular and surface expression of the HIV-1 coreceptor CXCR4/Fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J Immunol 160: 1522 -1531. | Tachibana, K. et al. (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393: 591-594. | Zou, Y.-R. et al. (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393: 595-599. | Wegner, S. A. et al. (1998) Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1. J. Biol. Chem. 273 (8): 4754-4760. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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