CD258 (LIGHT), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD258 (LIGHT), Human |
| Clone | REA244 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD258 (LIGHT) Antibody, anti-human, Biotin, REAfinity™. Clone REA244 recognizes the CD258 antigen, a type II transmembrane protein, which is also known as tumor necrosis factor ligand superfamily member 14 (TNFSF14), herpes virus entry mediator ligand (HVEML), or LIGHT, the acronym for ``homologous to lymphotoxins, inducible expression, competes with HSV glycoprotein D for HVEM, a receptor expressed on T lymphocytes''. CD258 is expressed by activated T cells, NK cells, monocytes, granulocytes, and immature dendritic cells. The ligands of CD258 are HVEM, lymphotoxin β receptor, and decoy receptor DcR3/TR6. CD258 has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. CD258 is also reported to prevent tumor necrosis factor alpha-mediated apoptosis in primary hepatocytes. Its blockade or targeted disruption can alleviate alloresponses, graft rejection, or graft-versus-host disease. | Additional information: Clone REA244 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | TNFSF14, HVEML, LIGHT, LTg, TR2 |
| Gene, Accession # | Gene ID: 8740 |
| Catalog # | 130-103-755 |
| Price | $264 |
| Order / More Info | CD258 (LIGHT), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Morel, Y. et al. (2000) Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J Immunol 165: 4397-4404. | Mauri, D. N. et al. (1998) LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8 (1): 21-30. | Heo, S.-K. et al. (2006) LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM. J. Leukoc. Biol. 79: 330-338. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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