TSPAN8, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TSPAN8, Human |
| Clone | REA443 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TSPAN8 Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA443 recognizes the human tetraspanin-8 (TSPAN8) antigen, a multi-pass membrane protein which is also known as transmembrane 4 superfamily member 3 (TM4SF3) or tumor-associated antigen CO-029. TSPAN8 is a member of the transmembrane 4 superfamily, which is a group of cell surface glycoproteins that contain four transmembrane domains and two conserved extracellular loops. Tetraspanins interact and form complexes with a wide variety of proteins, including other members of the tetraspanin family, integrins, receptors, and signaling molecules. Through these interactions, they play important roles in fundamental cellular processes such as migration, proliferation, and differentiation. It is suggested that TSPAN8 is widely expressed in various tissues, including in the digestive tract, connective tissue, bone, muscle, and kidney. TSPAN8 has also been intensively studied in the field of cancer. It has been shown to be highly expressed in colorectal, hepatocellular, and pancreatic carcinoma cells along with integrin family proteins. Several studies have suggested that TSPAN8 is also involved in the migration and invasion of cancer cells. | Additional information: Clone REA443 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CO-029, TM4SF3, Tspan-8, D6.1A |
| Gene, Accession # | Gene ID: 7103 |
| Catalog # | 130-106-814 |
| Price | $390 |
| Order / More Info | TSPAN8, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Szala, S. et al. (1990) Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Proc. Natl. Acad. Sci. U.S.A. 87 (17): 6833-6837. | Nazarenko, I. et al. (2010) Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 70 (4): 1668-1678. | Hirukawa, T. et al. (2014) Kidney diseases enhance expression of tetraspanin-8: a possible protective effect against tubular injury. Nephron Extra 4 (1): 70-81. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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