Podoplanin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Podoplanin, Human |
| Clone | REA446 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | 3D-Immunofluorescence, Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Podoplanin Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA446 recognizes the human podoplanin antigen, a 38-44 kDa mucin-type transmembrane protein which is also known as E11, GP38, OTS8, PA2.26, T1A, or aggrus. Podoplanin has a wide variety of functions including regulation of organ development, cell motility, tumorigenesis, and metastasis. It is expressed in multiple tissues during ontogeny and in adult, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. In lymphoid organs it is present in spleen four days postnatally. In adults, expression is detected on fibroblastic reticular cells, lymphatic endothelial cells, follicular dendritic cells in lymph node and spleen, and thymic medullary epithelial cells. Tumor cells often upregulate podoplanin as they undergo epithelial-mesenchymal transition and this upregulation is correlated with increased motility and metastasis. | Additional information: Clone REA446 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PDPN, Aggrus, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A |
| Gene, Accession # | Gene ID: 10630 |
| Catalog # | 130-128-175 |
| Price | $500 |
| Order / More Info | Podoplanin, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Herzog, B. H. et al. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502 (7469): 105-109. | Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem. J. 341 (Pt 2): 277-284. | Astarita, J. L. et al. (2012) Expression of tumor necrosis factor receptor 2 characterizes TLR9-driven formation of interleukin-10-producing B cells. Front Immunol 12 (3): 283. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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