CD172a (SIRPα), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD172a (SIRPα), Human |
| Clone | REA144 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD172a (SIRPα) Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA144 recognizes CD172a, which is also known as signal regulatory protein α (SIRPα). CD172a belongs to the Ig superfamily and is 75-110 kDa single-pass type I regulatory membrane protein. Expression of CD172a is found primarily on hematopoietic stem cells, neurons, and myeloid cells such as macrophages, monocytes, dendritic cells, granulocytes, and myeloid progenitors. CD172a phosphorylated at intracellular tyrosine sites, in response to extracellular stimuli, serves as the docking site for phosphatases such as SHP-1, SHP-2, or SHIP, which inturn desphosphorylate molecules involved in regulating various physiological effects. CD47 has been suggested as a ligand of CD172a. | Additional information: Clone REA144 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SIRPα, Bit, Mfr, MYD-1, P84, Ptpns1, SHPS-1, Sirp |
| Gene, Accession # | Gene ID: 140885 |
| Catalog # | 130-128-131 |
| Price | $141 |
| Order / More Info | CD172a (SIRPα), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Motegi, S. et al. (2003) Role of the CD47-SHPS-1 system in regulation of cell migration. EMBO J. 22 (11): 2634-2644. | Jung, C. J. et al. (2016) Comparative analysis of piggyBac, CRISPR/Cas9 and TALEN mediated BAC transgenesis in the zygote for the generation of humanized SIRPA rats. Sci Rep 6: 31455. | Oshima, K. et al. (2002) SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 519 (1-3): 1-7. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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