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Antigenic Specificity | CD21, Human |
Clone | REA940 |
Host Species | Recombinant Human |
Reactive Species | human, other |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD21 Antibody, anti-human, Biotin, REAfinity™. Clone REA940 recognizes the human CD21 antigen, a type I membrane glycoprotein. Expression of CD21 in humans is found on B cells, follicular dendritic cells, subsets of epithelial cells, and thymic T cells. The primary function attributed to CD21 has been to amplify the B cell receptor (BCR)-mediated signal transduction in response to antigen recognition. To enhance the BCR mediated activation, CD21 associates with CD19 and CD81 in a B cell-specific signal transduction complex, where interaction of BCR with CR2/CD19 amplifies the signals. In addition, CD21 serves as a receptor for split products of complement protein C3, the gp350/220 viral coat protein of the EBV and the immunoregulatory protein CD23. | Additional information: Clone REA940 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | CR2, C3dR, CR, CVID7, SLEB9 |
Gene, Accession # | Gene ID: 1380 |
Catalog # | 130-115-608 |
Price | $92 |
Order / More Info | CD21, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Roberts, M. L. et al. (1996) Epstein - Barr virus binding to CD21, the virus receptor, activates resting B cells via an intracellular pathway that is linked to B cell infection. Virology 77: 3077-3085. | Braun, M. et al. (1998) Human B and T lymphocytes have similar amounts of CD21 mRNA, but differ in surface expression of the CD21 glycoprotein. Int. Immunol. 10: 1197-1202. | Cherukuri, A. et al. (2001) The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. J Immunol 167: 163-172. | Barrington, R. A. et al. (2005) CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses. J Immunol 175: 2589-2867. |