CD304 (BDCA-4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-CD304 (BDCA-4), Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD304 (BDCA-4), Mouse |
| Clone | REA380 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD304 (BDCA-4) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA380 recognizes the mouse CD304 antigen, a single-pass type I membrane protein also known as neuropilin-1 or blood dendritic cell antigen-4 (BDCA-4). There are differences in the CD304 expression between mice and humans. In mice, CD304 is selectively expressed on natural T regulatory cells and greatly enhances immunosuppressive function. It is also expressed on a subset of invariant natural killer T cells, endothelial cells, and neurons. In humans, CD304 is expressed on plasmacytoid dendritic cells where it aids in priming immune responses and on a subset of T regulatory cells isolated from secondary lymph nodes. CD304 acts as a coreceptor for a number of extracellular ligands including class III/IV semaphorins, certain isoforms of vascular endothelial growth factor and transforming growth factor beta. It is involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits, and in organogenesis outside the nervous system. | Additional information: Clone REA380 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | NRP1, NP-1, NPN-1, Nrp |
| Gene, Accession # | Gene ID: 18186 |
| Catalog # | 130-127-898 |
| Price | $126 |
| Order / More Info | CD304 (BDCA-4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Delgoffe, G. M. et al. (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501 (7466): 252-256. | Yadav, M. et al. (2012) Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J. Exp. Med. 209 (10): 1713-1722. | Kawakami, A. et al. (1996) Developmentally regulated expression of a cell surface protein, neuropilin, in the mouse nervous System. J. Neurobiol. 29 (1): 1-17. | Smith, N. et al. (2017) Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 8: 14253. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies