TIGIT, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TIGIT, Mouse |
| Clone | REA536 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Mass cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIGIT Antibody, anti-mouse, APC, REAfinity™. Clone REA536 recognizes the mouse T cell immunoreceptor with Ig and ITIM domains (TIGIT) antigen, a single-pass type I membrane protein which is also known as V-set and transmembrane domain-containing protein 3 (Vstm3). TIGIT belongs to a PVR family of type 1 proteins that also binds to CD155 and CD112 ligands. It is expressed on peripheral memory and regulatory CD4+ T cells and NK cells and is upregulated following activation on naive CD4+ T cells. Its interaction with CD155 induces tolerogenic dendritic cells that impaire T cell proliferation and inhibit IFN-γ production from responding T cells. Like the well-characterized CD28/CTLA-4 costimulatory pathway, a newly emerging pathway consisting of CD226 and TIGIT has been associated with susceptibility to multiple autoimmune diseases. | Additional information: Clone REA536 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Vstm3, WUCAM |
| Gene, Accession # | Gene ID: 100043314 |
| Catalog # | 130-119-655 |
| Price | $93 |
| Order / More Info | TIGIT, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Joller, N. et al. (2014) Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory T?1 and T?17 cell responses. Immunity 40 (4): 569-581. | Stanietsky, N. et al. (2013) Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. Eur. J. Immunol. 43 (8): 2138-2150. | Pauken, K. E. et al. (2014) TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit. Cancer Cell 26 (6): 785-787. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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