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Antigenic Specificity | Ly-49D, Mouse |
Clone | REA1020 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | phycoerythrin (PE) conjugate |
Size | 150 µg in 1 mL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ly-49D Antibody, anti-mouse, PE, REAfinity™. Clone REA1020 recognizes Ly-49D, a type II transmembrane NK cell receptor belonging to the Ly-49 family. Members of the Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49D is a prototypic activating member of the Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. Expression of Ly-49D is strain restricted and is found on subsets of NK cells in C57BL/6, C3H/He, and SJL but not in BALB/c, DBA/2, AKR, and CBA/J mice. | Additional information: Clone REA1020 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Klra4, Chok, Klra32, Klra33, Ly-49d |
Gene, Accession # | Gene ID: 16635 |
Catalog # | 130-117-162 |
Price | $240 |
Order / More Info | Ly-49D, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635. | Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128. | Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11 (1): 67-77. |