CD276, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD276, Human |
| Clone | REA1094 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD276 Antibody, anti-human, PE, REAfinity™. Clone REA1094 recognizes the human CD276 antigen, a type I transmembrane protein expressed at low levels in human liver, lung, bladder, testis, prostate, breast, placenta, lymphoid organs, and many human cancers. Surface expression can be induced on T cells, natural killer cells, and macrophages as well as on dendritic cells (DC) by interferon γ (IFN-γ) and on monocytes by granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). CD276 has been shown to function as costimulatory molecule for T cell activation by inducing T cell proliferation and IFN-γ production. | Additional information: Clone REA1094 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | 4Ig-B7-H3, B7-H3, B7RP-2 |
| Gene, Accession # | Gene ID: 80381 |
| Catalog # | 130-118-570 |
| Price | $315 |
| Order / More Info | CD276, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat Immunol 2 (3): 269-274. | Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12640-12645. | Chen, Y. W. et al. (2008) The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Curr. Cancer Drug Targets 8 (5): 404-413. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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