CD104 (Integrin β4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD104 (Integrin β4), Mouse |
| Clone | REA456 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD104 (Integrin β4) Antibody, anti-mouse, PE, REAfinity™. Clone REA456 recognizes the mouse CD104 antigen, a single-pass type I membrane protein which is also known as integrin β4 (Itgb4). Integrins are a family of heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. CD104 interacts with α6 integrin and serves as receptor for laminin and component of hemidesmosomes. Expression of α6β4 integrin is found in the basal aspect of stratified epithelia such as epidermis, stratified squamous epithelium of squamous mucosa, urotheliumin, and certain tumor cells. CD104 is likely to play a pivotal role in the biology of invasive carcinoma. | Additional information: Clone REA456 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Itgb4 |
| Gene, Accession # | Gene ID: 192897 |
| Catalog # | 130-106-923 |
| Price | $66 |
| Order / More Info | CD104 (Integrin β4), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Murgia, C. et al. (1998) Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 17 (14): 3940-3951. | Pal-Ghosh, S. et al. (2011) MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. J. Cell. Sci. 124 (Pt 15): 2666-2675. | Simon-Assmann, P. et al. (1994) Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. Dev. Dyn. 201 (1): 71-85. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG