CD180 (RP105), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD180 (RP105), Mouse |
| Clone | REA957 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD180 (RP105) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA957 recognizes the mouse CD180 antigen, also known as RP105, a type I transmembrane protein structurally similar to toll-like receptors (TLRs) with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6-11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages, and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and in vivo, CD180 acts as an inhibitor of TLR4 signaling. | Additional information: Clone REA957 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Ly78, RP105 |
| Gene, Accession # | Gene ID: 17079 |
| Catalog # | 130-115-927 |
| Price | $64 |
| Order / More Info | CD180 (RP105), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Divanovic, S. et al. (2005) Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J. Endotoxin Res. 11: 363-368. | Divanovic, S. et al. (2007) Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J. Leukoc. Biol. 82 (2): 265-271. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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