C-peptide, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | C-peptide, Human |
| Clone | REAL1250 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | allophycocyanin (APC) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | C-peptide Antibody, anti-human, APC, REAdye_lease™. Clone REAL1250 is an antibody fragment derived from the full C-peptide antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1250 recognizes the C-peptide polypeptide, also known as connecting peptide, that connects insulin's A-chain to its B-chain in the proinsulin molecule. C-peptide has been shown to bind to the surface of a number of cell types such as neuronal, endothelial, fibroblast and renal tubular, at nanomolar concentrations to a receptor that is likely G-protein-coupled. The signal activates Ca2+-dependent intracellular signaling pathways such as MAPK, PLCγ, and PKC, leading to upregulation of a range of transcription factors as well as eNOS and Na+K+ATPase activities. C-peptide also has been reported to have anti-inflammatory effects as well as aid repair of smooth muscle cells. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | connecting peptide, Proinsulin, Insulin |
| Gene, Accession # | n/a |
| Catalog # | 130-129-678 |
| Price | $460 |
| Order / More Info | C-peptide, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Grunberger, G. et al. (2004) The C-peptide signaling. Exp Diabesity Res. 5 (1): 25-26. | Pujia, A. et al. (2017) An update on the potential role of C-peptide in diabetes and osteoporosis. Endocrine 58 (3): 408-412. | Yaribeygi, H. et al. (2019) The effect of C-peptide on diabetic nephropathy: A review of molecular mechanisms. Life Sci. 237: 116950. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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