RORγ (t), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | RORγ (t), Human/Mouse |
| Clone | REA278 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | purified |
| Size | 100 µg in 100 µL |
| Concentration | n/a |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | RORγ (t) Antibody, anti-human/mouse, pure, REAfinity™. Clone REA278 recognizes the retinoid-related orphan receptor-γ (RORγ) antigen and the RORγ (t) isoform, which are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed with highest levels in several tissues like muscle, kidney, and liver, whereas RORγ (t) is expressed almost exclusively in immature CD4+CD8+ double-positive thymocytes. RORγ is the possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivator recruitment. It is essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. RORγ (t) negatively regulates expression of Fas ligand and IL-2 production in T cells. It also binds to the TEA promoter and may be part of the pre-TCR activation cascade leading to the maturation of α/β T cells and may participate in the regulation of DNA accessibility in the TCR-Jα locus. | Additional information: Clone REA278 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | RORC, NR1F3, RORG, RZR-GAMMA, RZRG, TOR, NR1F3, RORgamma, TOR, Thor |
| Gene, Accession # | Gene ID: 6097 |
| Catalog # | 130-108-059 |
| Price | $205 |
| Order / More Info | RORγ (t), Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | He, Y. W. et al. (1998) RORγ t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9 (6): 797-806. | Villey, I. et al. (1999) RORγT, a thymus-specific isoform of the orphan nuclear receptor RORγ / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. Eur. J. Immunol. 29 (12): 4072-4080. | Jin, L. et al. (2010) Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ. Mol Endocrinol. 24 (5): 923-929. | Moretti, S. et al. (2017) A mast cell-ILC2-T?9 pathway promotes lung inflammation in cystic fibrosis. Nat Commun. 8: 14017. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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