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Antigenic Specificity | CD252 (OX40L), Rat |
Clone | ATM-2 |
Host Species | Mouse |
Reactive Species | rat |
Isotype | IgG1κ |
Format | allophycocyanin (APC) conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD252 (OX40L) Antibody, anti-rat, APC. Clone ATM-2 recognizes the rat CD252 antigen, a member of the TNF ligand superfamily, also known as OX40 ligand (OX40L) or tumor necrosis factor ligand superfamily member 4 (TNSFSF4). CD252 is constitutively expressed by splenic dendritic cells and can be upregulated on splenic B cells via stimulation with LPS. Expression of the cognate receptor CD134 (OX40) is found predominantly on activated T cells. CD252/CD134 interaction promotes the proliferation and survival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells, and inhibits the generation of inducible regulatory T cells. |
Immunogen | n/a |
Other Names | TNFSF4, OX40L |
Gene, Accession # | Gene ID: 89814 |
Catalog # | 130-104-301 |
Price | $88 |
Order / More Info | CD252 (OX40L), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Satake, Y. et al. (2000) Characterization of rat OX40 ligand by monoclonal antibody. Biochem. Biophys. Res. Commun. 270 (3): 1041-1048. | Paterson, D. J. et al. (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24 (12): 1281-1290. | Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98. |