LPAM-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | LPAM-1, Mouse |
| Clone | REA457 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LPAM-1 Antibody, anti-mouse, PE, REAfinity™. Clone REA457 recognizes the mouse Peyer's patch adhesion molecule 1 (LPAM-1) antigen, a heterodimeric glycoprotein receptor, which is also known as α4β7 integrin. LPAM-1 is a cell surface adhesion molecule involved in lymphocyte trafficking and lymphocyte-cell and matrix interactions. It is expressed on T and B cells. Lymphocytes in spleen and mesenteric lymph nodes have low levels of LPAM-1 expression but can up-regulate their LPAM-1 expression on activation. Cellular ligands include vascular cell adhesion molecule 1 (VCAM-1) and the mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is present on high endothelial venules of mucosal lymphoid organs. Interaction of LPAM-1 with MAdCAM-1 allows for tissue-specific migration of circulating lymphocytes into the lamina propria and Peyer patches of the gut. | Additional information: Clone REA457 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ITGA4, M290 IEL, Itga4B, Ly69, ITGB7, M290 IEL, CD49d |
| Gene, Accession # | Gene ID: 16401, 16421 |
| Catalog # | 130-120-290 |
| Price | $68 |
| Order / More Info | LPAM-1, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Petrovic, A. et al. (2004) LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 103 (4): 1542-1547. | Leung, E. et al. (1993) The mouse beta 7 integrin gene promoter: transcriptional regulation of the leukocyte integrins LPAM-1 and M290. Int. Immunol. 5 (5): 551-558. | Reese, S. R. et al. (2005) l-selectin and alpha4beta7 integrin, but not ICAM-1, regulate lymphocyte distribution in gut-associated lymphoid tissue of mice. Surgery 137 (2): 209-215. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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