CD62L, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD62L, Human |
| Clone | REA615 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | VioGreen conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD62L Antibody, anti-human, VioGreen™, REAfinity™. Clone REA615 recognizes the human CD62L antigen, a 74 kDa single-pass type I membrane protein, which is also known as L-selectin, LECAM-1, or LAM-1. CD62L is a member of the selectin family of cell surface molecules and binds a series of glycoproteins including CD34, GlyCAM-1, and MAdCAM-1. Most hematopoietic cells express CD62L, including peripheral blood B cells, T cells, monocytes, granulocytes, thymocytes, and some myeloid cells from bone marrow. Expression on resting naive, central memory, and some effector memory T cells regulates their migration via endothelial venules to peripheral lymph nodes and Peyer's patches. The CD62L antigen also contributes to the recruitment of leukocytes from the blood to areas of inflammation. Disruption of CD62L expression has detrimental effects on T cell migration and immune responses. Antigenic activation in the lymph node leads first to rapid CD62L shedding by protease cleavage and then to transcriptional suppression. | Always use fresh material for immunofluorescent staining of CD62L+ cells. For optimal results, the cells should not be older than 8-12 hours. Keep cells continuously cold. CD62L-expression may be rapidly lost due to shedding. | Additional information: Clone REA615 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | L-selectin, LAM-1, LECAM-1, Leu-8, TQ1, gp90-MEL |
| Gene, Accession # | Gene ID: 6402 |
| Catalog # | 130-130-587 |
| Price | $158 |
| Order / More Info | CD62L, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ivetic, A. (2013) Signals regulating L-selectin-dependent leucocyte adhesion and transmigration. Int. J. Biochem. Cell Biol. 45 (3): 550-555. | McEver, R. P. (2015) Selectins: initiators of leucocyte adhesion and signalling at the vascular wall. Cardiovasc. Res. 107 (3): 331-339. | Telen, M. J. (2014) Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors. Hematol. Oncol. Clin. North Am. 28 (2): 341-354. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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