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Antigenic Specificity | ASGPR1, Human |
Clone | REA608 |
Host Species | Recombinant Human |
Reactive Species | human, rat |
Isotype | IgG1 |
Format | Vio Bright FITC conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ASGPR1 Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA608 recognizes the human and rat asialoglycoprotein receptor 1 (ASGPR1) antigen, a single-pass type II membrane protein, also known as C-type lectin domain family 4 member H1 (CLEC4H1) or hepatic lectin H1 (HL-1). ASGPR1 is the major subunit of the asialoglycoprotein receptor (ASGPR) and is specifically expressed on the sinusoidal and basolateral hepatocellular membranes, but not on the bile canalicular membrane. It plays a role in the clearance of desialylated proteins from the serum through endocytosis and lysosomal degradation. | Additional information: Clone REA608 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Hepatic lectin, Asialoglycoprotein receptor 1, ASGP-R 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1, ASGR1, CLEC4H1 |
Gene, Accession # | Gene ID: 432 |
Catalog # | 130-109-490 |
Price | $162 |
Order / More Info | ASGPR1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Shi, B. et al. (2013) Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma. J. Histochem. Cytochem. 61 (12): 901-909. | Rigopoulou, E. I. et al. (2012) Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: lost and found. Autoimmun Rev 12 (2): 260-269. | Yang, J. et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J. Viral Hepat. 13 (3): 158-165. |