CD74, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD74, Human |
| Clone | REA1103 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD74 Antibody, anti-human, PE, REAfinity™. Clone REA1103 recognizes CD74, a non-polymorphic type II integral membrane protein. CD74 is also known as MHC class II-associated invariant chain and exists in multiple isoforms in human ranging from 33 to 43 kDa in size. Initially known for its role as the MHC II chaperone, CD74 primary function is suggested to regulate the MHC class II molecules folding and intracellular sorting. CD74 is also shown to form complexes with CD182 (CXCR2) and CD184 (CXCR4). A direct role of CD74 in the maturation of follicular B cells and accumulation of marginal zone B cells has also been suggested. CD74 was further shown to be one of the host molecules utilized by H. pylori to successfully attach to the gastric epithelial cells. Expression of CD74 is found on B cells, dendritic cells, epithelial cells, subsets of activated T cells, and low level expression is found on monocytes and macrophages. | Additional information: Clone REA1103 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | DHLAG, HLADG, II, Ia-GAMMA |
| Gene, Accession # | Gene ID: 972 |
| Catalog # | 130-119-203 |
| Price | $121 |
| Order / More Info | CD74, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Leng, L. et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197: 1467-1476. | Beswick, E. J. and Reyes, V. E. (2009) CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. World J Gastroenterol. 15 (23): 2855-2861. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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