Rb pS807/pS811, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Rb pS807/pS811, Human |
| Clone | REA691 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rb pS807/pS811 Antibody, anti-human, APC, REAfinity™. Clone REA691 recognizes the human retinoblastoma (Rb) antigen phosphorylated at serines 807 and 811. The Rb protein is a tumor suppressor that plays a pivotal role in the negative control of the cell cycle and in tumor progression. It has been shown that Rb is responsible for a major G1 checkpoint, blocking S-phase entry, and cell growth. Loss of Rb functions may induce cell cycle deregulation, leading to a malignant phenotype. Rb negatively regulates transcription by forming complexes with members of the E2F transcription factor family. These complexes, when bound to E2F sites within certain target genes, actively repress transcription through a variety of mechanisms including physical interaction with adjacent transcriptional activation domains and recruitment of proteins that directly, or indirectly, lead to histone deacetylation. Rb function is, in turn, modulated by phosphorylation mediated by cyclin-dependent kinases. Phospho-Rb is described as being hyperphosphorylated and when in this state, it is unable to complex E2F and therefore, unable to restrict progression from the G1 phase to the S phase of the cell cycle. During the M-to-G1 transition, phospho-Rb is progressively dephosphorylated by PP1, returning to its growth-suppressive hypophosphorylated state. | Additional information: Clone REA691 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110 |
| Gene, Accession # | Gene ID: 5925 |
| Catalog # | 130-110-979 |
| Price | $325 |
| Order / More Info | Rb pS807/pS811, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lee, W. H. et al. (1987) The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity. Nature 329 (6140): 642-645. | Nair, J. S. et al. (2009) Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780. Mol. Biol. Cell 20 (8): 2218-2228. | Rubin, S. M. (2013) Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem. Sci. 38 (1): 12-19. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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