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Antigenic Specificity | CD137, Human |
Clone | 4B4-1 |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG1κ |
Format | phycoerythrin (PE) conjugate |
Size | 100 tests in 200 µL |
Concentration | 1:50 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD137 Antibody, anti-human, PE. This antibody recognizes the CD137 (4-1BB) antigen, a 30 kDa glycoprotein of the tumor necrosis factor (TNF) receptor superfamily. CD137 is mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer cells, but can also be found on resting monocytes and dendritic cells. | As a costimulatory molecule it is involved in the activation and survival of CD4+ or CD8+ T cells, and NK cells. CD137 has been described to be a suitable marker for antigen-specific activation of human CD8+ T cells, as it is not expressed on resting CD8+ T cells and its expression is reliably induced after 24 hours of stimulation. |
Immunogen | n/a |
Other Names | TNFRSF9, 4-1BB, CDw137, ILA, 41BB |
Gene, Accession # | Gene ID: 3604 |
Catalog # | 130-119-885 |
Price | $315 |
Order / More Info | CD137, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Wolfl, M. et al. (2007) Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities. Blood 110: 201-210. | Wehler, T. C. et al. (2007) Targeting the activation-induced antigen CD137 can selectively deplete alloreactive T cells from antileukemic and antitumor donor T-cell lines. Blood 109: 365-373. |