CD181 (CXCR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD181 (CXCR1), Human |
| Clone | REA958 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD181 (CXCR1) Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA958 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, natural killer (NK) cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for interleukin 8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation. | Additional information: Clone REA958 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA |
| Gene, Accession # | Gene ID: 3577 |
| Catalog # | 130-115-952 |
| Price | $154 |
| Order / More Info | CD181 (CXCR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253 (5025): 1278. | Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J Immunol 162 (4): 2341-2346. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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