CD144 (VE-Cadherin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD144 (VE-Cadherin), Human |
| Clone | REA199 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright R720 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD144 (VE-Cadherin) Antibody, anti-human, Vio® Bright R720, REAfinity™. Clone REA199 recognizes CD144 (VE-Cadherin), a 120 KDa type II cadherin. Cadherins are cell adhesion molecules and mediate Ca 2)+ dependent homophilic interactions. CD144 contains five extracellular cadherin (EC) domains and like other cadherins can interact directly via its C-terminus with cytoplasmic proteins such as β-catenin, plaktoglobin, and p120. Plaktoglobin und β-catenin bind to α-catenin, which in turn interacts with several actin-binding proteins, α-actinin, ajuba, zonula occludens-1 (ZO-1). Further indirect interactions of CD144 with partners such as SHP-2, VEGFR-2, Csk, and PAR-3, 6 allows CD144 to not only regulate the stability and strength of cell adhesion but also to serve functions such as sensing of shear forces, anti-proliferative, and anti-apoptotic effects. | Additional information: Clone REA199 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CDH5, 7B4 |
| Gene, Accession # | Gene ID: 1003 |
| Catalog # | 130-131-568 |
| Price | $500 |
| Order / More Info | CD144 (VE-Cadherin), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Vincent, P. A. et al. (2004) VE-cadherin: adhesion at arm's length. Am. J. Physiol., Cell Physiol. 286: C987-C997. | Nelson, C. M. and Chen, C. S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell. Sci. 116: 3571-3581. | Odell, A. F. et al. (2012) A VE-cadherin-PAR3-α-catenin complex regulates the Golgi localization and activity of cytosolic phospholipase A2α in endothelial cells. Mol. Biol. Cell 23: 1783-1796. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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